Endocrine Abstracts

Objective: To know the GH secretory function in surgically cured acromegaly and its impact on quality of life of the patients.Subjects and methods: Sixty-seven acromegalics were judged to be surgically cured according to the Cortina consensus criteria and underwent postoperative insulin tolerance test (ITT) provoking hypoglycemia with nadir blood sugar under 50 mg/dl. All the patients underwent surgery under combined microscopic and endoscopic observatio...

Back ground: Encouraging responses of pituitary adenomas and pituitary carcinomas to temozolomide treatment have been well described and loss of immunopositivity of O6-methyl-guanine-DNA methyltransferase (MGMT) reportedly serves a predictor of good response. Recently some nonresponsive cases, however, also appeared. We describe here our own experiences of temozolomide treatment on three aggressive pituitary tumors.Subjects and methods: Three pitu...